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1 edition of Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation found in the catalog.

Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation

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Published by INTECH Open Access Publisher .
Written in English


Edition Notes

En.

ContributionsAna Sell, author
The Physical Object
Pagination1 online resource
ID Numbers
Open LibraryOL27077125M
ISBN 109535100130
ISBN 109789535100133
OCLC/WorldCa884209513

Theory Versus Reality. The underlying assumption of solid phase antibody testing was that it identified clinically relevant antibodies. Studies from numerous investigators reported of AMR and/or graft loss in patients who's donor‐specific antibody (DSA) were undetectable by complement dependent cytotoxicity assays but present by multiplex solid phase assays Cited by: Myc in stem cell behaviour: insights from Drosophila / Leonie M. Quinn, Julie Secombe, Gary R. Hime -- The Role of nuclear receptors in embryonic stem cells / Qin Wang, Austin J. Cooney -- Epigenetic regulation of stem cells / Anton Wutz -- Regulation of stem cell populations by microRNAs / Julie Mathieu, Hannele Ruohola-Baker --


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Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation by Jeane Visentainer Download PDF EPUB FB2

Some of the cytokine gene polymorphisms might be associated with severe, acute graft-versus-host disease after allogeneic stem cell transplant. We evaluated gene polymorphisms of IL-6 GC, TGF. Jeane Visentainer and Ana Sell (February 24th ).

Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation, New Advances in Stem Cell Transplantation, Taner Demirer, IntechOpen, DOI: / Available from:Author: Jeane Visentainer, Ana Sell. Middleton P.G. () Non-HLA Gene Polymorphisms in Stem Cell Transplantation.

In: Beksac M. (eds) Bone Marrow and Stem Cell Transplantation. Methods in Molecular Medicine, vol Author: Pete G. Middleton. Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation. By Jeane Visentainer and Ana Sell.

Open access peer-reviewed. Relevance of HLA Expression Variants in Stem Cell Transplantation. By Britta Eiz-Vesper and Rainer Blasczyk. Open access peer-reviewed. by: 5. Study of different genotypes of Vitamin-D Receptor (VDR) Gene Polymorphisms in Patients Eligible for Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) from a Sibling Donor Article Jan.

GVHD in HLA-matched sibling HSCT is due to donor T cells recognizing mHags in the recipient. mHags are peptides derived from intracellular proteins of restricted polymorphisms coded by, for example, autosomal Y chromosome genes, and are presented to T cells by specific HLA molecules (reviewed in []; see Table 1).Initial studies isolated T cell clones recognizing mHags in patients developing Cited by: C.

Harkensee, A. Oka, M. Onizuka, et nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study Cited by: 3. Extensive allelic matching in the human leukocyte antigen (HLA) genes is regarded as a prerequisite for good clinical success of allogeneic haematopoietic stem cell transplantation (HSCT).

Also other genetic factors can be assumed to play a role in preventing and controlling the complications associated with allogeneic HSCT, in particular graft-versus-host disease (GvHD).

Interleukin (IL Cited by: The outcome of hematopoietic stem cell transplantation (HSCT) is controlled by genetic factors among which the leukocyte antigen human leukocyte antigen (HLA) matching is most important. In addition, minor histocompatibility antigens and non-HLA gene polymorphisms in genes controlling immune responses are known to contribute to the.

The IHWG in Hematopoietic Cell Transplantation: a unique collaboration of the HLA research and clinical transplant communities. The studies of the International Histocompatibility Working Group (IHWG) in Hematopoietic Cell Transplantation (HCT) were presented at the 16 th International HLA and Immunogenetics Workshop in Liverpool in May, The projects within the working group Cited by: Genomic polymorphism and allogeneic hematopoietic transplantation outcome.

The importance of non-HLA genomics in nonmyeloablative transplants is poorly understood and is under investigation. These findings suggest that tissue typing for allo-HCT is entering an exciting era in which both HLA and non-HLA genomic data may be used in a more Cited by:   Non-HLA immunogenetics in hematopoietic stem cell transplantation Non-HLA immunogenetics in hematopoietic stem cell transplantation Dickinson, Anne M; Charron, Dominique Hematopoietic stem cell transplantation (HSCT) provides a unique environment in which to evaluate the role of immunogenetics of both the donor and the recipient to success of the.

Hematopoietic stem cell transplantation (HSCT) is an established therapeutic procedure for several congenital and acquired disorders, both malignant and nonmalignant.

Despite the great improvements in HSCT clinical practices over the last few decades, complications, such as graft vs. host disease (GVHD) and sinusoidal obstructive syndrome (SOS), are still largely unpredictable and remain the Cited by: 3.

Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study. Blood– (). CASCited by: 2. Hematopoietic Stem Cell Transplantation Invasive Aspergillosis Allogeneic Stem Cell Transplantation Chemokine Gene Nonrelapse Mortality These keywords were added by machine and not by the authors.

This process is experimental and the keywords may Cited by:   Hematopoietic cell transplantation (HCT) is a highly specialized, expensive and resource-intense medical procedure that can be associated with racial disparities. We review the prevailing Cited by: Organ transplantation has progressed with the comprehension of the major histocompatibility complex (MHC).

It is true that the outcome of organ transplantation largely relies on how well rejection is managed. It is no exaggeration to say that to be well acquainted with MHC is a shortcut to control rejection. In human beings, MHC is generally recognized as human leukocyte antigens (HLA).Author: Tsukasa Nakamura, Takayuki Shirouzu, Katsuya Nakata, Norio Yoshimura, Hidetaka Ushigome.

Introduction. Induced pluripotent stem cells (iPS), prepared by the introduction of four specific genes encoding the transcription factors Oct4, Sox2, Klt4, and c‐Myc, have the capacity to generate various tissues/organs al application in autologous settings in humans has just begun, such as in retinal regeneration However, autologous transplantation is hampered by the high time Cited by: 3.

In this special issue of Hematopoietic Stem Cell Transplantation, we invite research, comprehensive reviews, rare clinical cases, brief communications by experts in the field of Hematopoietic stem cell transplantation and relevant disciplines that cover a range of topics from basic science, translational research and clinical practice.

HLA Typing and Matching Multiple pre- and post-transplant factors including patient, disease stage, and transplant-related aspects can impact transplant outcomes. The degree of human leukocyte antigen (HLA) matching between the transplant recipient and the hematopoietic cell graft has a significant impact the outcomes of related and unrelated.

Abstract. We have examined the alleles of eleven minor histocompatibility antigens (MiHAs) and investigated the occurrence of immunogenic MiHA disparities in 62 recipients of allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning performed between and and in their HLA-matched sibling by: 6.

The human leukocyte antigen (HLA) system or complex is a group of related proteins that are encoded by major histocompatibility complex (MHC) gene complex in human. These cell-surface proteins are responsible for the regulation of the immune system in humans. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p HLA genes are highly polymorphic, which means that they have InterPro: IPR Molecular Methods: Stem Cell Transplantation presents a compendium of cutting-edge research on the molecular steps involved in hematopoietic stem cell (HSC) activation and self-renewal.

The emergence of HLA typing, and the positive impact it has had on the success of clinical transplantation is emphasized and discussed by notable stem cell. Purpose HLA mismatching increases mortality after unrelated donor hematopoietic cell transplantation.

The role of the patient’s germline variation on survival is not known. Patients and Methods We previously identified 12 single nucleotide polymorphisms within the HLA region as markers of transplantation determinants and tested these in an independent cohort of 1, HLA-mismatched unrelated Cited by: 1.

Back to Index 1. HLA- disease associations and transplantation 1. Review of the function and polymorphisms of HLA molecules Figure The distribution of the main genes that encode MHC class I and MHC class II molecules on the short arm of chromosome 6; the figure also shows the large number of allelic forms of most of these Size: KB.

Non-HLA Gene Polymorphisms and the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation Current Stem Cell Research & Therapy; The Management of Phosphodiesterase-5 (PDE5) Inhibitor Failure Current Vascular Pharmacology; Immune System Modulates the Function of Adult Neural Stem Cells Current Immunology Reviews.

Non-HLA Gene Polymorphisms and the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation Current Stem Cell Research & Therapy; Hypersensitivity to Aurora Kinase Inhibitors in Cells Resistant against Platinum- Containing Anticancer Agents Anti-Cancer Agents in Medicinal ChemistryCited by: 7.

download IMMUNOLOGY A Short Course 7th Edition Pdf for free. Hematopoietic Stem Cell Transplantation, Graft-versus-Host Disease, Xenogeneic Transplantation, The Fetus: A. OR8 Killer cell immunoglobulin-like receptor genotype BX1 and centromeric gene-content motifs influences survival after 3-models of allogeneic hematopoietic stem cell transplantation Bao, Xiaojing / Zhou, Huifen / Wang, Miao / Zhu, Wenjuan / Wu, Xiaojin / Wu, Depei / He, Jun | Non-HLA gene polymorphisms contribute to the immune response, leading to complications of haematopoietic stem cell transplantation (HSCT).

A systematic approach using 4, microsatellite (MS) markers typing for 3, immune response genes (‘immunogenome’) on pooled DNA of Japanese donors and recipients of HSCT was used to identify. B cells play a central role in the immunopathogenesis of glomerulonephritides and transplant rejection.

B cells secrete antibodies that contribute to tissue injury via multiple mechanisms. In addition, B cells contribute to disease pathogenesis in autoimmunity and alloimmunity by presenting antigens as well as providing costimulation and cytokines to T by: Shamim Z, Ryder LP, Christensen IJ, Toubert A, Norden J, Collin M, Jackson G, Dickinson AM, Muller K.

Prognostic Significance of Interleukin-7 Receptor-alpha Gene Polymorphisms in Allogeneic Stem-Cell Transplantation: A Confirmatory Study. Transplantation91(7), We launched a major program in Molecular Medicine and HIV research with focus on studying genetic polymorphism on a host of immunomodulatory genes.

Besides the above, I established the ‘Indian Marrow Donor Registry (IMDR)’ which has proved most valuable in. Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online.

Easily share your publications and get them in front of Issuu’s. We found that carrying the risk allele rs*T lowered the cell-surface expression of CD40 in all tested B cell subtypes (in total B cells P ≤ × in patients and ≤ × in controls), while carrying the risk allele rs*G increased the expression of CD86, with this effect primarily seen in the naïve B cell subset.

A LeuPro mutation of the non-HLA gene IL18RAP in aggressive neonatal type 1 diabetes mellitus. Abstract PDF. P1-D Papillary thyroid cancer after hematopoietic stem cell transplantation in young age. Abstract PDF.

Association of ghrelin gene polymorphisms with obesity in. Jon was involved in the first successful pediatric bone marrow transplantations in Europe in He was instrumental in the establishment of Europdonor (present day Matchis) and Bone Marrow Donors Worldwide (BMDW) which are crucial for many successful.

Influence of single nucleotide polymorphisms in the BCL11A and HBS1L-MYB gene on the HbF levels and clinical severity of sickle cell anaemia patients. Ann Hematol. Jun;95(7)(IF: ) Disha S Parchure, Swati S Kulkarni.

Celiac disease has become one of the best-understood HLA-linked disorders. Although it shares many immunologic features with inflammatory bowel disease, celiac disease is uniquely characterized by (1) a defined trigger (gluten proteins from wheat and related cereals), (2) the necessary presence of HLA-DQ2 or HLA-DQ8, and (3) the generation of circulating autoantibodies to the Cited by:   Uses of expanded cord blood hematopoietic stem/progenitor cells (HSPC) are described.

Examples include to reduce transplant rejection, to induce immune tolerance, to reduce total parenteral nutrition (TPN) feeding, opioid use, mucositis, and hospitalization following a medical procedure and to reduce graft versus host disease (GVHD) following an allogeneic by: 1.

Hum Immunol. Jan 27;: Authors: Liu J, Yu Q, Zheng S, Jiang Y, Liu Y, Yuan G, Qiu L PMID: [PubMed - as supplied by publisher] (Source: Human Immunology) Retraction notice to "Aberrant frequency of ILproducing b cells and its association with Treg and MDSC cells in Non Small Cell Lung Carcinoma patients" [Hum.How to ultimately use MRD in deciding on the need for hematopoietic stem cell transplantation has not yet been fully established but is likely to play a role, particularly when tested after induction Hematopoietic Stem Cell Transplant (HSCT) It has been difficult to demonstrate a favourable impact of stem cell transplantation in adult ALL.Though kidney transplantation is considered a routine procedure, there are still significant challenges in post-transplant management.

Core Concepts in Renal Transplantation is a clinically focused authoritative guide to the management of kidney transplantation.

This comprehensive, state-of-the-art reference summarizes the recent changes in the field of transplantation, offering the complete.